TY - JOUR AU - Eck, Andrew G. AU - Lopez, Kevin J. AU - Henderson, Jeffrey O. PY - 2018/12/31 Y2 - 2024/03/28 TI - RNA-binding Motif Protein 45 (Rbm45)/Developmentally Regulated RNA-binding Protein-1 (Drbp1): Association with Neurodegenerative Disorders JF - Journal of Student Research JA - J Stud Res VL - 7 IS - 2 SE - DO - 10.47611/jsr.v7i2.417 UR - https://www.jsr.org/index.php/path/article/view/417 SP - 33-37 AB - <p>Neurodegenerative disorders are caused by the progressive loss of the structure and/or function of neurons, often through cell death, contributing significantly to morbidity and mortality. Cytoplasmic aggregation of proteins into inclusion bodies is a pathological characteristic of amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer’s disorder (AD). These inclusion bodies have been shown to contain RNA-binding proteins participating in RNA-dependent and RNA–independent protein:protein interactions.</p> <p>RNA-binding motif protein 45 (RBM45), also known as developmentally regulated RNA-binding protein-1 (Drbp1), was first identified as a novel RNA binding protein in rat that functions in neural development. Advancing research has indicated a connection between the presence of human RBM45 protein cytosolic aggregates and degenerative neurological diseases. This review considers the structure, function, and distribution of RBM45 along with a look into potential future research on this multifunctional RNA-binding protein.</p> ER -