RNA-binding Motif Protein 45 (Rbm45)/Developmentally Regulated RNA-binding Protein-1 (Drbp1): Association with Neurodegenerative Disorders


  • Andrew G. Eck Judson University
  • Kevin J. Lopez Judson University
  • Jeffrey O. Henderson Judson University
Keywords: Alzheimer’s disorder (AD), amyotrophic lateral sclerosis (ALS), Drbp1, frontotemporal lobar degeneration (FTLD), Rbm45

Abstract


Neurodegenerative disorders are caused by the progressive loss of the structure and/or function of neurons, often through cell death, contributing significantly to morbidity and mortality. Cytoplasmic aggregation of proteins into inclusion bodies is a pathological characteristic of amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer’s disorder (AD). These inclusion bodies have been shown to contain RNA-binding proteins participating in RNA-dependent and RNA–independent protein:protein interactions.

RNA-binding motif protein 45 (RBM45), also known as developmentally regulated RNA-binding protein-1 (Drbp1), was first identified as a novel RNA binding protein in rat that functions in neural development. Advancing research has indicated a connection between the presence of human RBM45 protein cytosolic aggregates and degenerative neurological diseases. This review considers the structure, function, and distribution of RBM45 along with a look into potential future research on this multifunctional RNA-binding protein.

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Author Biographies

Andrew G. Eck, Judson University
B.A. Biochemistry, 2017
Kevin J. Lopez, Judson University
B.A. Biochemistry, 2014
Jeffrey O. Henderson, Judson University

Professor of Biology

Department of Science and Mathematics

 


Published
12-31-2018

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How to Cite
Eck, A. G., Lopez, K. J., & Henderson, J. O. (2018). RNA-binding Motif Protein 45 (Rbm45)/Developmentally Regulated RNA-binding Protein-1 (Drbp1): Association with Neurodegenerative Disorders. Journal of Student Research, 7(2), 33-37. Retrieved from https://www.jofsr.org/index.php/path/article/view/417
Section
Review Articles